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Noninvasive molecular imaging approaches include nuclear, optical, magnetic resonance imaging, computed tomography, ultrasound, and photoacoustic imaging, which require accumulation of a signal delivered by a probe at the target site.
Each individual step and its transition to the next require accumulation of aberrations associated with an intricate network of genes.
Single dose regimens would also be preferable but the long action of PQ may require accumulation of concentration over three days.
Given that DCL1 has limited or insignificant activity on perfectly-paired dsRNA, acquisition of DCL1-dependence and subsequent formation of discrete small RNA products from the foldback precursor may require accumulation of drift mutations that result in foldback mispairs.
Since Alexa 488-anti-CD147 did not stain a JN spot in these cells, the transport of Abs to CFs apparently does not require accumulation of the Ab in the ERC, suggesting that Ab internalisation may not be required.
Considering that improvement of complex traits such as n-butanol tolerance might require accumulation of much more adaptive mutations [ 31, 32], the pQ-lib carrying cells were transferred in each n-butanol concentrations for three times, upon full growth, before transferring to the next higher butanol concentration.
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This is understandable as pursuance of either pastoral or agro-pastoral livelihoods required accumulation of a viable livestock herd and access to assets for farming.
The short range movement (up to 10 15 cells) of the silencing signal requires accumulation of 21nt but not of 24nt siRNA while the possibility that ssRNA move from one cell to the other cannot be yet ruled out.
Although some single point mutations are sufficient to render HIV resistant to individual drugs, escape from combination regimens requires accumulation of multiple mutations, which often appear in specific patterns.
Recovery from such global glaciation was also probably slow because it required accumulation of very high CO2 levels [ 166].
Association mapping using a genome-wide approach still requires accumulation of sufficient genomic resources in five needle pines.
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