In this review, we want to motivate the international community to design more standardized animal models which might help to address the legally requested replacement, refinement and reduction of animals in fibrosis research.
User Interface Improvements – The June08 Update also includes numerous customer-requested refinements to the Dash Express interface, making it even more intuitive for daily use.
Constructive critique of survey design, content, structure, user acceptability and time for completion was requested, following which further refinement was undertaken.
During my appearance on Gates's show, it was all the way up to 18.9%, which had him joking that I was getting blacker by the year; then, during a recent retest requested by Gates after further refinement of the science, it was down to 5.7%.
"Garden of Lights" had a lot of support, a juror said, but the support evaporated after a "very unfortunate last presentation" in which the design team failed to satisfy requests for refinements.
A refinement phase, corresponding to the finishing phase, with a mean number of 9.1 ± 2.2 aligners on the upper arch and 6.7 ± 3.1 on the lower arch was requested for each case: during the refinement phase, each aligner was worn for 10 days.
As the reviewers requested, we tested the 2-start helical symmetry, but the refinement did not converge and the axial rise went continuously from the correct 16.7 Å to the incorrect 19.5 Å after 50 runs.
Numerical experiments with five representative examples of difficult-to-simulate kinetic models reveal that the reduction of the computational time, the number of spatial grid nodes needed, and spatial grid refinement levels, is particularly noticeable when a high spatial accuracy of the simulations is requested.
If the surface exhibits regular areas (e. g. a microchip surface), areas measured in each refinement iteration become smaller and smaller, up to a point where all data are measured with the requested z precision.
