Sentence examples for repurposing against from inspiring English sources
Moreover, known targets of DB02082 and DB02623 share the same depth of GO annotation as FtsZ suggesting that the predicted drugs could be explored for repurposing against FtsZ.
These drugs can be repurposed against Mtb.
Besides the anti-infectives, non-anti-infective agents have also been repurposed against TB.
Meanwhile, a case where an intentionally built-in backdoor was possibly repurposed against US government systems is currently under investigation by the House Oversight Committee.
Many of the drugs like Fluoroquinolones (Gatifloxacin and Moxifloxacin); rifamycins (Rifapentine and Clofazimine); oxazolinones (Linezolid and Sutezolid); and beta lactams (Meropenem and Clavulanate) have been repurposed against MDR/XDR TB [12].
In addition, methods based on structural proteome of Mtb by Kinnings et al. [20] and identification of polypharmacological drugs by Ramakrishnan et al. [21] have also reported repurposing candidates against Mtb proteins.
The activity of Digoxin has been found in multiple drug repurposing screens against many targets, including cancer and HIV.
A network-driven approach guiding the selection of prioritized drugs can be immensely advantageous in terms of cost and efficiency in the beginning phases of drug discovery and can offer significant implications to future drug repurposing strategies against a variety of NTDs.
Given that these inhibitors were designed as anti-inflammatory drugs for use in humans and fit the Lipinski rule-of-five (including bioavailability), they show promise for hit-to-lead optimisation and repurposing for use against parasitic nematodes.
To identify opportunities to repurpose inhibitors against disease-associated mutant kinases, we conducted a large-scale functional screen of 183 known kinase inhibitors against 76 recombinant mutant kinases.
Repurposing old drugs has emerged as a novel paradigm to develop drugs against infectious diseases particularly of the developing world, as it allows saving of time and resources during drug development.
