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Similarly, both telomerase-dependent and independent mechanism may coexist in the iPSCs reprogramming process.
However, the reprogramming process mediated by the traditional defined factors (OSMK) is slow and extremely inefficient.
In addition, miR-29b is upregulated by SOX2 during reprogramming process and overexpressing miR-29b promotes the iPSC formation.
In addition, as we discuss below, dissecting miRNA targets could also provide insights on the mechanism of reprogramming process.
Endogenous Nanog levels are only re-established in later phases of the reprogramming process [19].
The epigenetic pre-treatment of somatic cells could be used to improve the efficiency of reprogramming process.
The macrophage reprogramming process is characterized by four phenomena.
However, as long as the expression of exogenous Oct4 is transient, the reprogramming process progresses.
PRC proteins are also implicated in the somatic cell reprogramming process [ 40, 41].
Nonetheless, some familiar drawbacks exist, such as a longer and less efficient reprogramming process.
Therefore, the reprogramming process accurately re-established nucleosome organizations highly similar to ESCs.
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