Sentence examples for reprogramme it from inspiring English sources

To our knowledge, this study demonstrates for the first time that limited oncogene expression in CSCs is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that CSC elimination is enough to eradicate the whole tumour.

We conclude that limited oncogene expression in a CSC is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that BCR-ABLp210-induced CML is reversible through the unique elimination of the CSC.

Overall, our data show that oncogene expression in Sca1+ cells is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that elimination of the CSCs is enough to eradicate the whole tumour.

Here, we demonstrate that ADEPs do not merely inhibit the physiological functions of ClpP but reprogramme its activity in a highly sophisticated manner.

Such initiatives aim to reprogramme the state and make it feedback-friendly, crowding out other means of doing politics.

Learning how to manipulate or reprogramme the inflammatory response so it is most effective at staving off infection, and then able to switch to repair mode, and finally to resolve in a timely fashion to avoid the chronic inflammatory phenotype so common in persistent chronic wounds, would provide superb therapeutic tools.

Even if some studies have questioned the regenerative potency of various endogenous progenitor populations, it is clearly feasible to reprogramme many cell types to differentiate into cardiomyocytes.

However it is sometimes possible to reprogramme one differentiated cell type to another by overexpression of specific transcription factors which are responsible for the relevant commitment processes in normal development [ 2].

Although it has been possible to reprogramme somatic cell nuclei by transplantation into a suitable donor cytoplasm for decades [ 53– 55], the discovery of four genes (Oct4, Sox2, c-Myc and Klf4; referred to hereafter as the four factors) whose overexpression could convert fibroblasts into iPSCs (induced PSCs) opens the door for reprogramming on a biomedically relevant scale [ 56].

Similarly to Esrrb, Klf4 and Klf5, Prdm14 is also a transcriptional target of Nanog ([ 33 ] and Figure 2), and its ability to reprogramme EpiSC underscores the overlap in characteristics between migratory PGCs and ES cells.

It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism.