We hypothesized that MF would be capable of growth-inhibiting cancers of reproductive and non-reproductive origin regardless of PR expression, displaying cytostatic effects at lower micromolar concentrations and lethal effects at higher micromolar doses.
In this study we questioned whether the growth inhibitory properties of MF observed in ovarian cancer cells would translate to other cancers of reproductive and non-reproductive origin and, importantly, whether its efficacy is related to the expression of cognate PR.
In this study we sought to extend our findings in ovarian cancer cells to cancer cell lines of alternate tissues of origin, including cancers of both reproductive and non-reproductive origin, and questioned whether the expression of PR was related to the sensitivity of the cancer cells to the growth-inhibitory influence of MF.
This work developed and became known, eventually, as the "out of testis" hypothesis, where the testis, the male reproductive organ, is the origin for the birth and evolution of new genes (Kaessmann 2010).
A prototypical instance is that of the pulsatile secretion pattern of GnRH (gonadotropin releasing hormone), the master hormone controlling the reproductive function, whose origin remains a puzzle issue since its discovery in the seventies.
Their geographic origins, reproductive modes, host aphids and morphotypes are summarized in Table 2.
Despite the relevance to human health and reproductive technologies, the origins and developmental dynamics of mammalian sexual dimorphism have not been characterized in detail.
According to Blumberg, the findings also support an evolving concept in reproductive biology the "developmental origins of health and disease" hypothesis, which holds that low-dose chemical exposures or maternal dietary changes experienced in utero can induce permanent physical changes in adult animals.
(2010) found no significant difference in reproductive success of wild-origin and first-generation hatchery-origin steelhead derived from the same gene pool.
These two theories of the origin of reproductive isolation are not mutually exclusive.
Precise mechanisms of reproductive heritability and the origin of new traits remained a mystery.
