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However a recent study that examined the effects of a phthalate mixture (which included DnBP but not DEP) on female rat offspring exposed in utero reported reproductive malformations consistent with the Mayer Rokitansky Kuster–Hauser syndrome [ 7].
Furthermore, DiNP exposure in rats during gestation and perinatally increased the incidence of reproductive malformations in male offspring and caused alterations in fetal testicular testosterone production (Borch et al. 2004; Gray et al. 2000).
Age and abstinence time [ 33, 37- 42], BMI [ 43], season of sampling [ 44- 48], and previous reproductive malformations and diseases [ 49, 50] have all previously been found to be associated with different measures of male reproduction and where thus considered as potential confounders.
All diets for all groups exceeded the allowable daily intakes (ADI) derived by the US Consumer Product Safety Commission CPSCC) for the risk of aspermatogenesis (5.8 μg/kg-day) while diets high in meat and dairy consumption exceeded the ADI for reproductive malformations in females (11.5 μg/kg-day) [ 59].
Recent studies have reported that pairs of phthalates (Borch et al. 2004) or combination of a phthalate with another anti-androgen with a different mode of action (Hotchkiss et al. 2004) produce dose-additive effects on male reproductive malformations in rats.
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This study was undertaken to evaluate the diagnostic management and the reproductive outcome after surgical repair of a rare reproductive malformation.
The manifestations of TDS are thought to result from perturbations to fetal testis development, altering fetal testis hormone production and causing subsequent reproductive malformation and disease (Sharpe and Skakkebaek 2008).
Diethylstilbestrol (DES), a synthetic estrogen that was prescribed in the 1940s 1970s to prevent miscarriage, is a prototype EDC that causes reproductive tract malformations and cancers in exposed populations.
For DBP, Mylchreest et al. (2000) found androgen-dependent effects from exposure in rats, such as decreased AGD, retained areolas or nipples, and reproductive tract malformations.
Developmental exposure to diethylstilbestrol (DES) causes reproductive tract malformations, affects fertility and increases the risk of clear cell carcinoma of the vagina and cervix in humans.
Clinical issue In utero exposure to endocrine-disrupting chemicals (EDCs) is associated with reproductive tract malformations, cancer, obesity and type 2 diabetes later in life.
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