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The combined dataset includes 933 chemicals, with 693 having only in vitro data and 189 having only in vivo mammalian long-term reproduction data.
There were no differences between treatments for any of the serum analytes, reproduction data, or incidence of disease for retained placenta, displaced abomasum, lameness, mastitis, and culling.
Pasture production and quality data, milk and milk component data, and reproduction data were collected, averaged for SR treatment, and linear and quadratic contrasts on SR were evaluated.
Using both experimental and simulated data, our analyses highlighted several statistical issues related to the fitting of DEBtox models on OECD-type reproduction data.
Three-way ANOVA on log-transformed reproduction data of all clones together did not detect a statistically significant Cd × Microcystis interaction term (F-test, p = 0.11), meaning that on average both stressors do not interact in inhibiting reproductive performance of D. magna.
From those results, we conclude that the triplet method can be used to assess the quality of reproduction data stored in dairy herd management software and that a machine learning technique such as random forests is capable of predicting the correctness of fertility data.
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In summary, quantitative analysis shows a good degree of reproduction of data from near the electrojet by the limited number of parameters used in AMM.
Taking into account the thresholds derived from two reproduction toxicity data bases a drinking water limit of 3.0 μg/L is proposed.
This is demonstrated by examination of 309 chemicals tested in the U.S. Environmental Protection Agency EPAA) ToxCast™ phase I project (Knudsen et al. 2011) and of 40 chemicals for which fathead minnow 21-day short-term reproduction assay data have been reported in the peer-reviewed literature.
Reproduction and milking data for each cow are registered continually, as well as data on production and feeding at herd level.
As these predictions were analyzed, more complex conditions were seen to be necessary for a satisfactory reproduction of experimental data.
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