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Since tendon overuse injuries and tendinopathies are accompanied by inflammation through up-regulation of proinflammatory cytokines, matrix metalloproteinase (MMP) expression, and prostaglandin E2 (productionuction, which could initiate the degradation and remodeling of tendons [ 31, 32], we tried to reproduce these changes in tendon cell culture.
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These results open a new avenue into the exploration of the effects and regulation of neurogenesis during chronic neurodegeneration, and offer a new model to reproduce the changes observed in human neurodegenerative diseases.
The Simplified cAMP Model A was tested to see if it could reproduce the changes in cAMP levels observed experimentally during a glucose pulse.
Although we cannot conclude that these biophysical mechanisms are the only ones involved in these developmental transitions, our experiments demonstrate that manipulating these parameters quantitatively reproduces the changes in electrical phenotype observed between these stages (see Figure 11E).
The slope-background is designed to empirically reproduce the change on the slope.
We used numerical simulations with the goal of reproducing the changes in GPS TEC that were observed one day prior to the strong mid-latitude earthquake in Greece on 8 January 2006.
Similarly to observations made in the SSC, the effects of the three anesthetics on CA1 dendritic spines were dependent on the age of the animals (Fig. 4b), thus reproducing the changes observed in the SSC.
The stress induced by simple laminectomy can have an effect on spinal cord tissue which partially reproduces the changes induced by traumatic injury.
Moreover, to better elucidate the effects of IL-17 on PM, intraperitoneal IL-17 was injected in mice, reproducing the changes that normally take place in PD patients.
It reproduces the changes observed in human disease states due to localized tissue injury (Malik et al. 2010a; Ramadori and Christ 1999; Sheikh et al. 2006), making it an ideal model for studying the metabolic consequences of human APR.
They were not, it seems also, practised fraudsters: they did not apparently employ the common technique (in fraud) of properly recording data from an initial relatively small sample and then reproducing these data repeatedly with minor changes – which produces a large dataset with a degree of verisimilitude (unless, by chance, the initial sample happened to be atypical).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com