Roquin, an RNA-binding E3 ligase regulates Icos mRNA stability through the repressive action of a particular miRNA (miR-101) (Vinuesa et al, 2005; Yu et al, 2007), though again, the requirement for its E3 ligase activity remains unclear.
What you have, then, is old-fashioned Iraqi tribalism masquerading as "Arab socialism," repressive social control passing for "social stability".
During the dictatorship of President Mobutu Sese Seko (1965 1997), when the country was named Zaire, the repressive government provided periods of relative stability but at great cost to the country and to its citizens.
The view I have come to is that the stability of corrupt and violently repressive dictatorships in Middle Eastern states like Gaddafi's in Libya is false stability.
The differences in the levels/patterns of repressive chromatin modifications/chromatin compaction along the repressed hCD2 transgene and the stability of hCD2 repression in two different hCD2 transgenic lines (CD2 1.3A14 and CD2 1.3B) suggested an unequal contribution of DNA methylation and H3K9me3 to maintenance of hCD2 repression.
Speaking at the end of a five-day trip to Europe and Turkey, Mr. Bush acknowledged that Western nations have helped nourish extremism by supporting repressive Middle Eastern leaders for the sake of regional stability.
For decades, successive U.S. Republican and Democratic administrations have supported repressive Arab regimes in the name of the "stability" of a strategic, oil-rich region.
PER proteins have a fundamentally important role within the mammalian circadian clock, as changes in their post-translational modification state throughout the day exert exquisite control over the stability and localization of early PER CRY repressive complexes.
On the Republican side, a long-running argument has raged between neoconservatives and so-called realists, who are more willing to tolerate repressive governments if they advance American interests and preserve stability.
Taking these observations into consideration, miR-433 acts as a repressive regulator, but is not responsible for the decreased mRNA stability due to the 6-bp deletion.
