The repression of Cebpa by multiple factors expressed in alternative lineages suggests that hematopoietic genes are organized into densely interconnected repressive networks instead of hierarchies of mutually repressive pairs of pivotal TFs.
Moreover, as demonstrated previously (Balaskas et al., 2012; Panovska-Griffiths et al., 2013), changing the binding affinities of the TFs forming the cross-repressive network altered the pattern and behaviour of gene expression (supplementary material Fig. S6K-BB).
Although bacterial protein domains are often modular, the ease with which eukaryotic activators can be converted into inhibitors via differing exon usage, raises interesting questions about their potential to evolve antagonistic or self-repressive networks.
The strongest weapons available to our enemies are ideas of religious supremacy and perennial confrontation, backed with logistical networks, and repressive political conditions that help strengthen their narrative and network.
Another notable observation is that most repressive interactions in the network (Fig. 1) arise from pairs of genes.
We propose that flux-limited competition could be a common mechanism for introducing repressive interactions in cellular networks, and we argue that switching behavior similar to that described here should occur generically in systems that implement such a mechanism.
My feeling is that repressive regimes repress.
While many activists depend on social networks to organize, repressive regimes are also becoming adept at using the same networks to identify "enemies of the state". Tech companies may try to pretend they are neutral in these battles, but when it comes to Internet freedom, there's no Switzerland.
With respect to the metastasis-repressive response arm, Myc activation results in a global repression of an extensive network of ECM and adhesion proteins that govern cell migration and invasiveness.
Social media companies trumpet how pro-democracy protesters use their networks to oppose repressive governments.
