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"After a period of accommodation with the Islamic groups, the regime entered this far more proactive and repressive mode.
Experimental data show that a repressive mode, where the presence of a resource disables the binding of a repressor to the DNA, is preferred when demand for expression is rare, whereas an activating mode is preferred in the opposite situation [8].
Thus, in repressive mode, BMP signalling causes phosphorylation of Smad1, which promotes its association with Smad4 in mouse chondrocytes.
Previous studies of individual genes have shown that in a self-enforcing way, dimethylation at histone 3 lysine 9 (dimethyl-H3K9) and DNA methylation cooperate to maintain a repressive mode of inactive genes.
Remarkably in contrast, however, the "tobacco-responsive elements" from −2.9 to −4.4kb were critical for an increase in activity in response to cigarette smoke extract, whereas our results point to a strikingly repressive mode of action [see Supplemental Material, Figure 3 (http://www.ehponline.org/members/2008/0800311/suppl.pdf)].
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For the lac system and realistic time variations, the entropic effects appear to be so large that only a repressive regulatory mode is possible [9].
"It was a fundamentalist, repressive way of life," Gavin says.
LncRNA genes exhibiting repressive expression rate modes did not reveal any significant GOs (See Figure 9 for their heatmaps, along with the ones of the associated positively correlating proteins).
My feeling is that repressive regimes repress.
Such observations agitate Gadamer's critics, who see in the unreflective acceptance of the given an irresponsibly conservative privileging of the received, a wilful blindness to possible repressive or exclusionary practices within inherited modes of operation.
A second mode of trans-repression found for the prostate-specific antigen (PSA) gene occurs independently of NKX3.1 promoter binding sites, but through repressive interaction with transcriptional activators such as SP1 and prostate-derived ETS factor (PDEF ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com