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This mechanism contributes approximately two-fold to repression, indicating that additional repressive mechanisms are used by miRISCs to achieve maximal target silencing.
Taken together, these data suggest a relative opening by reduction of constitutive heterochromatin markers is accompanied by increased levels of two heterochromatin markers associated with different repressive mechanisms, which may maintain the repressed subtelomeric chromatin state upon senescence.
Therefore, we tested whether chromatin repression was actually maintained, by involvement of different repressive mechanisms instead.
Initiation of XCI is followed by maintenance of the repressed state, through the synergistic action of several repressive mechanisms (Csankovszki et al, 2001).
Our second task, then, is to develop forms of collective action that exceed the repressive mechanisms set up to contain them.
Genetic enhancer screens have revealed roles of miRNAs and other gene repressive mechanisms in development or other cellular processes that were masked by genetic redundancy.
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In Bambi vs. Godzilla, a collection of tough-minded essays about the film business, the award-winning playwright turned screenwriter and director posits a repressive mechanism to account for our appetite for dramas that have ceased to be dramatic and entertainments that barely entertain.
She bravely responded by releasing a statement on Aug. 31st, 2011, stating: "Direct all of the force of your repressive mechanism, which includes assault, car accidents, murders and the whole arsenal, against me personally, a woman whose only weapon is a word.
Likewise, it has been postulated that epigenetic silencing may be the ICP0-antagonized repressive mechanism that is capable of silencing the HSV genome [20], [55].
Thus, the repressive mechanism involving Spt5 is rapidly reversible.
We speculate that when HP1a silencing is compromised, PRC2 becomes the back-up repressive mechanism.
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