Exact(6)
This correlation is most likely indirect, due to repressive interaction between gt and Kr.
A target-protector morpholino (TP MO) causes rbpj overexpression by abolishing the repressive interaction between Celf1 protein and rbpj mRNA (Cibois et al., 2010b).
A second mode of trans-repression found for the prostate-specific antigen (PSA) gene occurs independently of NKX3.1 promoter binding sites, but through repressive interaction with transcriptional activators such as SP1 and prostate-derived ETS factor (PDEF ).
Interestingly, we also observed 1,369 significant overlaps between a set of genes upregulated by factor X and a set of genes downregulated by factor Y, suggesting a repressive interaction between X and Y factors.
It was predicted that an additional mechanism should be involved in the repressive interaction to create a bistable switch, and therefore a third unspecified gene was introduced to create bistability.
This suggests that the lack of anthocyanin production in betalain-producing species may be due to a lack of transcriptional activation of all the necessary biosynthetic genes [ 7, 23], although a hypothesis based on repressive interaction between anthocyanin and betalain metabolites and the biosynthetic enzymes has also been suggested [ 24].
Similar(53)
In summary, our results indicate that mutual repression between hb and kni is conserved, but the strength of these repressive interactions differs considerably between M. abdita and D. melanogaster: we detect weaker inhibition of kni by hb and stronger inhibition of hb by kni.
We propose that flux-limited competition could be a common mechanism for introducing repressive interactions in cellular networks, and we argue that switching behavior similar to that described here should occur generically in systems that implement such a mechanism.
In addition the network in Figure 3(c) has more repressive interactions than either the template network or the other optimized network in Figure 3(b).
These repressive interactions serve to restrain Wnt1 to its medial domain, in order to generate and maintain an anterior zero-to-very low Wnt activity zone, which is required for the development of forebrain fates.
Transcription of Brachyury is also modulated by repressive interactions.
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