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In such a condition, possibility of the presence of male repressive factor in untreated plants and its de-repression by AgNO3 molecule in treated wild type female and GyM-F cannot be ruled out.
These results are also consistent with previous reports that DNA methylation is a dominant repressive factor, and that TSA alone may not de-repress gene transcription if the gene is densely methylated [ 15].
DBC1 would serve as a transcriptional repressive factor to manipulate transcriptions, thereby influencing transcriptional products such as SIRT1 and p21.
These results provide novel insights into the complex role that this Polycomb repressive factor plays in normal development and gliomagenesis.
Moving on, Marcus Buschbeck pointed out that a similar contribution to differentiation gene activation had been previously observed for yet another "repressive" factor, the histone variant macroH2A.
These data indicate that PARN is the repressive factor depleted by Gld-2 injection and that it is the ejection of PARN from the polyadenylation complex that induces cytoplasmic polyadenylation [74].
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A study by Kilmon and colleagues [ 46] demonstrated that macrophages regulate B-cell tolerance by secreting regulatory factors like IL-6 and CD40L and that macrophages from lupus-prone MRL/lpr mice are less capable of repressing Ig secretion coincident with reduced secretion of these repressive factors.
Sumoylation can have an inhibitory role in transcription by leading to the recruitment of repressive factors with chromatin remodeling activity or by initiating the formation of repressive complex [18].
Indeed, gonadal dysgenesis is determined during early development at late embryonic stages and reflects simply a maternally-transmitted property (deposition of maternal P repressive factors in the cytoplasm of the oocyte) [30], [47].
Balance between activating and repressive factors may control the ratio [3], although such a model does not account for the preferential inactivation of the subset of cistrons that might be interrupted by transposable element.
We speculate that the intragenic enhancer may be marked in early embryogenesis by pioneer factors that maintain an open, poised chromatin status [ 22] and prevent assembly of repressive factors associated with the spreading of Kcnq1ot1 [ 4, 5].
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