Sentence examples for repressive elements from inspiring English sources

Our results support a model in which constitutive activation of Olig2 by its basal promoter is repressed in undifferentiated cells by upstream repressive elements until that repression is relieved during differentiation.

Further studies in yeast identified an amino-terminal linker-domain as well as a loop in the DNA binding domain as repressive elements that contributed to HSF1 repression in both yeast and mammalian cells [26], [27].

Further studies in yeast also identified an amino-terminal linker-domain, a loop in the DNA binding domain, as well as several phosphorylation sites as repressive elements that contributed to HSF1 repression in both yeast and mammalian cells (Liu and Thiele 1999; Ahn et al. 2001; Batista-Nascimento et al. 2011).

The expression of Olig2 is likely repressed in undifferentiated cells through the concerted action of upstream repressive elements including the ULTRA and, possibly, two other regions [38].

Under Mr. Chávez repressive elements of daily life coexist with humane social-welfare policies.

Despite the fact there have always been anti-intellectual, progress-resistant, or socially oppressive and repressive elements within southern culture, the south is not to be defined by its lowest common denominator.

This also suggests KDM2B can function as a Polycomb group repressive element (PRE) to inhibit differentiation gene expression (He et al., 2013).

Another region on our candidate list (mm8_chr16: 91,080,626 – 91,082,625; Table 2) may contain a repressive element (DIG, unpublished data).

Having identified the potentially active and repressive element, we used quantitative chromatin immunoprecipitation (qChIP) to map a variety of histone modifications in the Hoxa9 locus, as represented by amplicons 1 4 (Fig. 1A) in three different cell lines, each expressing a distinct level of Hoxa9 (Fig. 1E).

The luciferase reporter assay demonstrated that the core promoter ranged from −307 to −207, and a possible repressive element resides between positions −707 and −508.

37 39 Furthermore, the work presented here in chondrogenic cells demonstrates that site specific mutations of the RBPjk binding site (proposed by Chen et al. as the repressive element) does not yield any change in Notch-mediated suppression of Sox9.