Sentence examples for repressive domain from inspiring English sources

To establish whether Math6 activates or represses transcription and if Math6 possesses an intrinsic repressive domain, we cotransfected an expression vector encoding full-length Math6 fused to a heterologous DNA-binding domain (GAL4-DBD) with a high basal activity reporter plasmid containing 5 copies of the GAL4 DNA binding site upstream of prolactin promoter-luciferase [35].

Finally, this experiment also demonstrated that UBE1, ATRX and MECP2 were always located at the periphery of the repressive domain, as do genes escaping XCI in mice [49].

The N-terminal region of posterior Hox genes contains the repressive domain.

Hence, all PRC2 targets would also become PRC1 targets and a repressive domain would be established.

Thus, it would be interesting to determine whether the loss of the aromatic repressive domain was associated with the loss of the PAX8 locus in birds.

Those exons code for a sterile α motif (SAM) domain and a repressive domain located at that end of the protein [ 2].

However, unlike the mammalian chromatin loops that are enriched at the TAD border, plant chromatin loops are often formed between gene islands outside the repressive domains and are closely associated with active compartments.

These data indicate that TIEG1 likely utilizes multiple binding sites located throughout the Runx2 promoter and furthermore suggest that repressive domains, which reduce the ability of TIEG1 to activate this promoter, are contained within the distal regions of the Runx2 promoterter.

Are active and repressive domains spatially partitioned?

It is intriguing that the loss of two putative repressive domains is accompanied by a gain of an N-terminal polyalanine repeat.

We also observe a significant sequence divergence of the N- and C- terminus of the avian FOXE1 proteins and a loss of two repressive domains.