Sentence examples for repression of essential from inspiring English sources
The inhibition of cell growth usually associated with squelching is likely caused by the transcriptional repression of essential genes or a lethal combination of nonessential genes.
It has been hypothesised that the phenomenon of GC cytotoxicity in lymphoid tissues is related to the repression of essential metabolic pathways in these cells (Tonko et al, 2001), indicating that there may be a distinctive metabolic phenotype associated with this tissue type.
Although mild-to-moderate environmental exposures may not alter basic genetic information (DNA sequence), these exposures can determine the expression or repression of essential genes at developmentally critical points (Dolinoy et al. 2007; Li et al. 2003), thus contributing to chronic disease.
The proliferative arrest is mediated by transcriptional repression of genes essential for cell division by the retinoblastoma protein family.
The joined repression of both essential GIST oncogenes could be promising for GIST treatment, especially for imatinib-resistant disease.
In hematological malignancies, increased HDAC activity may lead to transcriptional repression of genes essential for hematopoietic differentiation, playing a critical role in the pathogenesis of several leukemias.
Repression of retrotransposons is essential for genome integrity and the development of germ cells.
Repression of HO is essential in diploid cells because it prevents switching of one of the MAT loci to form homozygous a/ a or α/ α diploid cells.
HSF1-dependent induction of apoptosis in spermatocytes seems to be caused by the simultaneous repression of many genes essential for spermatogenesis.
Genetic studies reveal that the antiviral function of AGO18 depends on its activity to sequester microRNA168 (miR168) to alleviate repression of rice AGO1 essential for antiviral RNAi.
Also, repression of Uhrf1, the essential co-factor for the Dnmt1 maintenance methyltransferase, observed in wild-type PGCs [ 4], does not occur in mutant cells.
