Many of the impacted splicing events are part of an epithelial splicing program, suggesting that effects of Msis on splicing may reinforce the effects of Jag1 repression on maintenance of epithelial cell state.
As per the current concept, H2A ubiquitination contributes to specific transcriptional repression programs, maintenance of genome stability, and DNA repair, whereas H2A deubiquitination is associated with transcriptional activation, cell cycle transition, as well as tuning of genome stability and target gene activation in cancer cells.
The Polycomb Repressive Complexes mediate the initiation of gene repression and its maintenance.
The stemness-off modules were composed of 39 homolog and 23 functional modules each representing putative programs requiring active repression for the maintenance of stemness (Dataset S1).
The loss of Otx2 repression and Gbx2 maintenance by CHD7 are predicted to result in reduced Fgf8 expression in Chd7- deficient embryos.
SCMH1 is a core component of polycomb repressive complex 1 (PRC1) [ 16- 18] which is involved in the maintenance of repression and can block chromatin remodeling[ 17], and it plays an important role in regulation of homeotic genes in embryogenesis[ 19].
Recent advances, particularly through genome analyses and cellular studies, increased our understanding of various local factors and cellular processes associated with the development, maintenance and repression of the corpus luteum.
KNOXI proteins and cytokinin, a plant hormone intimately associated with the regulation of cell division [7, 8], share overlapping roles, such as meristem maintenance and repression of senescence [2, 9 11], but their mechanistic and hierarchical relationship have yet to be defined.
Thus NELF is not involved in the stable maintenance of repression at these later stages, which involves instead other mechanisms such as epigenetic maintenance by the Polycomb group proteins and specific histone methylation marks [28], [29], [30].
Furthermore, increased REV activity in zll-1 restores ARF2 repression and stem cell maintenance.
In addition, phosphorylation affects self-recruitment of EZH2 to its own mark, which may have bearing on maintenance of repression throughout cell divisions [ 53, 54].
