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However, the relationship between epigenetic switches and more dynamic patterns of gene activation and repression has remained largely unknown.
However, to date, no Pcl-containing complexes have been purified and the role of Pcl in PcG repression has remained enigmatic.
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The mechanism of X chromosome inactivation has been subject to many studies, but the genetic requirements for initiation of gene repression have remained elusive.
The glucose sensing mechanism involved in activation of the Snf1 protein kinase in the main glucose repression pathway has remained unclear.
It is well known that p53 transcriptionally activate genes that contain a p53 binding site, but the underlying mechanism for transcriptional repression by p53 has remained largely unexplored (Ho and Benchimol, 2003; Huarte et al., 2010; Leonova et al., 2013; Menendez et al., 2009; Riley et al., 2008).
Previous work has revealed cross talk between the cAMP-PKA pathway and the glucose repression pathway, but the precise connection between the two pathways has remained unclear.
A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important open topic.
Pena has remained productive.
Jones has remained firm.
He has remained fit.
The repression added a new dimension to the protests with peasant farmers warning they would take up arms, a threat that so far has remained rhetorical.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com