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A homolog of a flowering time gene has evolved a flowering repression function, affecting the seasonal cold response in beet.
It is known that the CTCF-mediated repression function is partially sensitive to the HDAC-inhibitor Trichostatin A (TSA) [35].
This indicates that HDACs are not only involved in the repression function of CTCF, but also in enhancer blocking.
Next, we tried to identify specific amino acid sequences within the N-terminus which are responsible for the repression function of AmphiVent1.
It is therefore likely that these RNAs were independently recruited into their current repression function at a later time in mammalian evolution during which increasing brain complexity required more stringent translational control mechanisms.
In order to see whether KlROX1 has a transcriptional repression function similar to that of the S. cerevisiae ROX1, a Δklrox1 null mutant was constructed and used in the investigation of oxygen response in K. lactis.
Similar(29)
Here, we showed that the EBF1 C-terminal domain (CTD) is required for the regulation of a specific gene set involved in B cell fate decision and differentiation, independently of activation and repression functions.
NKX2.2 transcriptional repression functions through recruitment of Groucho-family corepressors.
DNA-binding transcription factors, such as nuclear receptors, bind nearby to genes and mark them for activation or repression, functions subsequently effected by the recruitment of coregulators.
Parallels between the transcriptional repression functions of Blimp1 and germ plasm (in other models) have been noted elsewhere (Surani et al., 2004; Nakamura and Seydoux, 2008).
Furthermore, since both activation and repression functions can be achieved with crisprTFs, the crisprTF platform may be advantageous compared to noncoding RNA-based gene regulatory platforms where only repression can be achieved.
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