Sentence examples for repressing mark from inspiring English sources

More recently, however, it became apparent that arginine methylation can be either an activating or a repressing mark that regulates the expression of multiple genes.

In human CRC adenocarcinoma cell line (Caco-2), there was enrichment for H3K4me3 (p  < 1.0 x 10−6) and a suggestive enrichment for H3K36me3 (p  = 0.060), but no significant enrichment for the repressing mark H3K27me3 (p  = 0.86) (Additional file 9).

Even the same type of modification, on the same histone and residue, can be activating or repressing depending on the underlying sequence context; for example, methylation of H3K36 is enhancing transcription if the affected histone resides in the coding region of a gene, but it is a repressing mark in the promoter region [ 5].

To date, various genome targeting domains and epigenetic modifiers have been used to direct activating or repressing marks to desired loci (reviewed in [ 15, 49- 51]).

Indeed, a H3K4 methyltransferase called PfSet10 colocalizes with the previously active var gene locus in post-ring stages, whereas repressing marks are excluded from this site, presumably contributing to the poised state (Volz et al., 2012) (Fig. 1B).

The reduction in repressed marks, together with the increase of active marks in ASC, suggests a favorable balance for the expression of differentiation genes in these cells, while the differences observed between MSC-ADSC and MAPC suggest that epigenetic mechanisms are probably involved in determining the different potential of these populations of adult stem cell.

EZH2 specifically methylates lysine 27 of histone H3 (H3K27), a repressive chromatin mark associated with gene silencing [10], [11], [12] and often represses target genes associated with growth control.

Furthermore, our data confirm that PcG proteins are involved in repressing bivalently marked developmental genes in ES cells [28] [31].

A comprehensive RRBS study by Meissner et al. included data on LCP promoters showing that in some cases methylation changed during tissue differentiation correlating with activating or repressing histone marks.

Consistent with the expression analysis, we observed that these three miRNAs showed an increase of H3K27m3 and H3K9m3 repressed chromatin marks and a decrease of open chromatin marks in ASC in comparison with NTERA-2 (Figure 6).

This concurs with the observation that most of the genes repressed in stem cells by Polycomb-repressive marks also contain histone-active marks [4].