Sentence examples for repressed without from inspiring English sources

Two large scale proteomic studies published very recently have shown that, although some microRNA target proteins are repressed without detectable changes in mRNA levels, more than a third of translational repressed targets also display detectable mRNA destabilization and, for the more highly repressed targets, mRNA destabilization usually makes up the major component of repression [ 19, 20].

Some were repressed without detectable changes in mRNA levels.

All conditional knockdown mutants were TetON mutants and expression of the targeted gene was induced with anhydrotetracycline (atc) or doxycycline (doxy) and repressed without atc/doxy.

However, it has been demonstrated that although some targets are repressed without detectable changes in mRNA levels, those translationally repressed by more than a third also displayed detectable mRNA decreases, and, for the more highly repressed targets, mRNA degradation usually comprised the major component of repression.

Translation initiation can also be repressed without disrupting the closed-loop.

Although one-third of mRNAs repressed in the translation process display detectable destabilization, more are repressed without detectable changes in mRNA levels [ 50].

This is consistent with a model where PPARβ/δ represses without an endogenous ligand and that binding of ligand to the receptor causes recruitment of transcriptional proteins and increased transcription after forming a transcriptional complex that increases transcription and/or outcompetes the repressive complex for repression.

Neurotics repeat the desired act in repressed form, without conscious memory of its origin or the ability to confront and work it through in the present.

Moreover, fly Ago-RISC associated with target mRNA in a manner independent of GW182 and repressed translation without affecting eIF4E recognition of the cap (Fukaya et al., 2014), further arguing against the idea that Ago binding to the cap is required for translation repression.

Of all developmentally repressed genes without promoter DMRs that were assessed, none are enriched for H3K9me3 or H4K20me3 (n = 11; data not shown).

The high levels of de-repression in the absence of Tup1p suggest that this subset of genes is predominantly repressed by Cyc8 Tup1 without possible compensatory repression mechanisms; in the absence of the co-repressor these genes are constitutively switched on.