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The Kaplan-Meier curves show a significant separation between the induced, basal, and repressed module activities on both the Vijver et al. [4] data (p<0.0001), and the Wang et al. [3] data (p = 0.0098).
In another case, both ploidy- and meiosis-related genes are reassigned from the strongly induced Module 5 in the typically haploid pre-WGD species to the unchanged Module 3 or repressed Module 2 in the typically diploid post-WGD species.
As in the response to glucose depletion, similarity in heat stress profiles is inversely proportional to phylogenetic distance, and the strongly repressed Module 1, which consists of 'growth' genes, is the most conserved (Roy et al., 2013).
Conversely, a repressed module activity shows the best outcome.
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Induced modules are depicted by positive values and repressed modules by negative values.
In our study non-recurrent tumors showed significantly repressed modules, namely cell-cell signaling and extracellular region, which contains POSTN.
To determine if any of the enriched modules were capable of segregating samples on phenotype we built contingency tables across clinical conditions from each of the data sets (Tomlins [ 5] and Ramaswamy [ 6]) for induced and repressed modules and tested for sample enrichment using a Fisher's Exact test.
In sum, if the reprogramming factors repress module A, then: since some protein still remains in the cell.
Hybrid local regulators repress modules involved in anabolism while they activate modules involved in catabolism.
If reprogramming factors activate and repress module A at the same time, then:.
Segal et al. [ 46] used predefined biologically meaningful gene sets including known biological pathways, and have successfully identified activated or repressed biological modules in a wide variety of neoplastic conditions.
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