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Seierstad, looking unflinchingly at the repressed condition of Afghan women, "is a sharp and often lyrical observer," our critic, Richard McGill Murphy, wrote.
But her account of living in the family of an English-speaking Kabul bookseller, whom she portrays as a liberal to the world and a tyrannical patriarch at home, also shocked Nordic audiences with its intimate look at the repressed condition of Afghan women.
To further confirm the differential sensitivity to MMS and HU in the P MET3-MMS22 strain in the repressed condition, we checked the viability of the strains during a 12-hr period of MMS or HU exposure.
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In no case did we observe binding at any promoter tested under repressed conditions, and we present here data after four hours of derepression.
More surprisingly, pph21Δ pph22Δ behaved more or less like WT, both in derepressed and repressed conditions, whereas deletion of RTS1 led to a small increase in phosphorylation in both conditions.
Thus, after pre-growth both strains were transferred to media containing D-glucose as a repressing condition, sophorose as an inducing condition, and no carbon source as a control condition respectively, and incubated for 3 hours.
Snf1 is the yeast homolog of the AMP-activated protein kinase, and activation of Snf1 in repressing conditions relieves some glucose repression of ADH2 and other Adr1-dependent genes, allowing up to 10% of derepressed transcription levels [8], [10].
Macrophage killing was significantly attenuated in the conditional mutant grown under repressing conditions compared to the controls.
Nonetheless, the hyper-active Adr1c proteins are still sensitive to glucose repression and respond to activation of Snf1 in repressing conditions, pointing to regulation beyond the potential Ser230 modification [8], [10].
Thus, under repressing conditions, the mutant produces highly branched hyphae.
There was no significant difference (P > 0.05) between the growth of this strain at different NFAP concentrations under PkcA repressing conditions in contrast to the isogenic recipient A. nidulans R153 (P < 0.0001) (Table 1).
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