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miRNAs act to repress expression of their target genes via mRNA cleavage or translational repression.
This experiment suggested that the small amount of HIF-1α expressed at 3 h (see Fig. 4A) is able to repress expression of FGF2.
The catecholamine epinephrine is known to repress expression of hepatic drug metabolizing enzymes such as cytochromes P-450.
Interestingly, MaERF11 also interact with MaHDA1, the complex repress expression levels of downstream genes targeted by MaERF11 via histone deacetylation (Han et al. 2016).
SimR is known to repress expression of simX and its own gene by binding to two distinct operators within the simR/simX intergenic region Le et al. 2009.
This system, which we call CRISPR interference (CRISPRi), can efficiently repress expression of targeted genes in Escherichia coli, with no detectable off-target effects.
An increasing number of catabolic pathways under the control of specific regulators are now known to be influenced by the presence of alternative carbon sources, which to different extents repress expression of the pathway despite the presence of the inducer.
Testosterone has previously been shown to repress expression of genes encoding lipogenic enzymes in adipose tissue [42].
To investigate the interdependence of WG and BRK, we asked if BRK alone is sufficient to repress expression of the dpp reporter.
Considered in Targetscan, the 15 nucleotides after the stop codon in a 3' UTR form poor microRNA target binding sites that show little ability to repress expression.
CsrA was recently shown to repress expression of the Bacillus subtilis flagellin gene, hag, by preventing ribosome binding to the transcript [48].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com