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Hypothesizing that inhibition of ARF-regulated bone remodeling would repress development of OS, we demonstrated that treatment of Tax+Arf-/ mice with zoledronic acid, a bisphosphonate inhibitor of OC activity and repressor of bone turnover, prevented or delayed the onset of OS.
Therefore, overexpressed miRNAs at pluripotent state primarily repress development.
Together, miRNAs primarily and directly repress development during the pluripotent state while they repress metabolism and pluripotency during cell differentiation.
In this circuit, miRNAs directly repress development and directly repress the DNA methylation system, while miRNAs indirectly regulate pluripotency genes.
Possibly, developmental regulatory cues, such as those thought to modulate tadpole growth [ 17], specifically target and repress development of immunogenetically dissimilar conspecifics.
This suggests that one of miRNA primary functions is to repress development at the pluripotent state to prevent stem cell differentiation and to keep stem cell pluripotency while miRNAs also degrade pluripotent core factors to facilitate differentiation during differentiation state.
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This is consistent with our discussion above on the miRNA repressing development and differentiation at the pluripotent state in stem cells (Figs. 2 and 3).
For example, in the posterior abdomen Abd-B functions cooperatively with the sex determination transcription factor Doublesex (Dsx) repressing development of the terminal male abdominal segment (A7) and promoting male-specific pigmentation on A5 and A6 (Kopp et al., 2000; Wang and Yoder, 2012; Wang et al., 2011).
These result suggested that, at the intermediate stage under cold stress, low temperature began to repress the development and growth of vegetative organ in the paper mulberry.
This suggests an unexpected role for ethylene perception in the stamens that serves not only to repress stamen development, but also to promote carpel development.
In addition to the proliferation and cell death defects of scrib mutant clones, we have also observed that they cooperate with activated alleles of dRas1 (RasACT) RasACT or Notch (NACT) to repress pupal development and, throughout an extended 'giant larvae' phase of development, form massive and invasive tumours [ 2, 3].
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