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It acts in the hypothalamus to repress appetite, and in the liver and AT to stimulate lipolysis and inhibit lipogenesis through activation of AMPK.
The two currently available antiobesity drugs, orlistat and phentermine, which block intestinal fat absorption by inhibiting pancreatic lipase and repress appetite, respectively, are not very effective.
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This recognition that the hypothalamic NPY circuit is the conductor of the appetite-regulating network in the brain has paved the way for novel therapies designed to subjugate hypothalamic NPY signaling for tonically repressing appetite and, thereby, curb the current worldwide escalation in the incidence of obesity and the attending metabolic syndrome.
Appetite is the ruling principle, repressed sexual appetite in particular: almost all murders have lust at their core (sexual blackmail over lurid photographs in "The Big Sleep"; incest in Robert Towne's "Chinatown," which is really the culmination of Chandler on film).
These preliminary details, coloured by mythology, sexual politics, desire and appetite both repressed and sated, might lead the reader to think that Michèle Roberts's new novel is desperately overwritten, at once self-consciously lyrical and striving for both sensuousness and significance.
The lifting of visas hinges on Turkey rescinding the anti-terrorism legislation, which Mr Erdoğan uses to repress dissent – and he shows no appetite of giving up.
As I satisfied my spiritual appetite, I started dating girls in order to repress my sexual desires.
The whole person is out of whack, the spirit repressed to the point of death, but because the physical aspect of the human person is in control, appetite comes first and last.
They repress trade rivals.
Is his appetite off?
And his appetite!
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