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The use of composites for the wave spring represents significant challenges in not only understanding the elastic response, but also the failure and fatigue characteristics.
Ultimately, although the rodent literature has helped inform us about experimental design for thimerosal studies, the small size of mouse pups represents significant challenges particularly when administering IM thimerosal (Harry et al. 2004).
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But overturning the legally agreed pay deals of thousands of workers could represent significant challenges.
Clinical trial design and study population selection are also areas that represent significant challenges to testing any putative neuro-protective agent.
Understanding the inherent variability of process rates, critical thresholds and likely potential influence of unpredictable perturbations represent significant challenges to predicting the natural environment.
Global changes such as climate change and demographic change next to a more diverse urban society and restricted municipal budgets represent significant challenges urban planning has to deal with today and in the near future.
These narrative forms represent significant challenges for the management of the hepatitis C epidemic, both in terms of the existing risk reduction efforts designed for HIV and in terms of the articulation of risk reduction for injectors with general public health policy.
Drug toxicity and emergence of drug resistant mutant viruses also represent significant challenges [4].
These diseases already represent significant challenges for health-care systems in most parts of the world.
The feminization of ageing and an increasing number of older women living alone with multiple chronic conditions represent significant challenges to health services and societal support systems.
Increasing numbers of cancer survivors, the broad range of issues they may experience, inadequacies of current models of care, limited health-care staffing and rising health-care costs represent significant challenges to the provision of ideal survivorship care.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com