Sentence examples for represents potent from inspiring English sources
Together with the Hsp90 molecular chaperone machinery, a complex interplay between ERs, co-activators, co-repressors and growth factor-activated membrane pathways represents potent targets which warrant to be manipulated alone and in combination to designing novel therapies.
Liver disease and liver transplantation represent potent risk factors for OD [103].
Stressful life events represent potent risk factors for the development of internalizing symptoms among adolescents.
TMC-95's natural cyclic tripeptide metabolites represent potent competitive proteasome inhibitors.
More than 200 scaffolds with broad target coverage were identified that consistently represented potent compounds and yielded an abundance of scaffold hops in the low-nanomolar range.
However, the tertiary methylamines trans-11 and cis-11 represent potent σ1 ligands with Ki-values of 43 and 24 nM, respectively.
The novel compounds presented here represent potent broad-spectrum biochemical inhibitors of bacterial MAP and have the potential to lead to the development of new medicines to combat serious multi-drug resistant infections.
Compounds 3 8 represent potent alkaloids isolated from Crinum sp. (Amaryllidaceae), which exhibit acetylcholinesterase inhibition, the most active alkaloids isolated being hamayne (7, IC50 = 250 μM) and lycorine (5, IC50 = 450 μM), while the other alkaloids were comparatively inactive, with haemanthamane (6) giving 3%% inhibition and crinamine (8) giving 4.4 % inhibition at 50 mg mL−1 (174 μM).
The Bcl protein family represent potent inhibitors of the FASL-mediated apoptotic pathway [27].
Capsule production is associated with tissue invasiveness [15] and has been reported to be inversely related to biofilm growth [16], while capsular polysaccharides represent potent cytokine-inducing stimuli [17].
The immunophilin-binding agents cyclosporine A (CsA), FK506 and rapamycin represent potent immunosuppressive agents that have revolutionized bone marrow and solid organ transplantation as well as treatment of autoimmune diseases.
