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Since bone accounts for more than 94% of the adult body burden of lead, bone lead level by K-X-ray fluorescence represents lead content in the cortex of tibia and the patella trabecular [ 2].
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If this process represents lead-related hyperfiltration, the associations between lead dose and uric acid may become positive as this population ages and eventually, as in the Normative Aging Study, be stronger in those with the ALAD2 allele than in those with the ALAD1-1 genotype.
These inhibitors represent lead compounds for further development of MtOPRT inhibitors with increased potency, which may be tested as anti-TB agents.
Half of the identified hits most likely belong to known classes of GAD inhibitors, but several substances have not been described previously as GAD inhibitors and may represent lead optimization entry points for the design of arthropod-specific parasiticidal compounds.
Natural cationic host defense peptides represent lead molecules that boost innate immune responses and selectively modulate pathogen-induced inflammatory responses [45].
Plant-derived bioactive compounds are attractive candidates for drug development since they represent lead structures for new or existing drug targets.
Hence, higher enrichment scores represent lead functional GO-groups.
Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Glucosides, plant-derived compounds with glucose bound to a functional, non-sugar group (aglycone), have been shown to inhibit glucose diffusion in S. mansoni [ 4, 42] and could therefore represent lead compounds for developing drugs targeting glucose transport.
InsP5 and 2- O-Bn-InsP5 may represent lead compounds to develop novel inhibitors of the PI3K/Akt pathway (including potential dual PDK1/mTOR inhibitors) and novel potential anti-cancer drugs.
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