Liver failure resulting from hepatitis B (HBV) represents difficult-to-treat conditions.
Thus the viruses in this panel for the most part represented difficult to neutralize viruses.
However, while relevant biological information is implicit in the links between multiple domains, annotations from these different domains are usually represented in distinct, unconnected DAGs, making links between the domains represented difficult to determine.
The queries that are generated may have limited readability and could be difficult to represent.
In case of unrealistic volume since the first calculation step, it would be difficult to represent the contributions of various secondary minerals.
The perception that government warnings or media stories represent scare mongering may be difficult to tackle but requires further attention.
Molecular functions arise from complicated sets of physical interactions between large numbers of proteins, RNAs and various regulatory pathways, which can be difficult to reconstruct, represent and analyse.
From a practical and technical perspective, the zonal architecture and microenvironments exhibited in mammalian liver represent difficult challenges to incorporate simultaneously into a single device or culture platform.
This may overall represent difficult disease biology to treat.
To account for this apparent inconsistency, Watkins (2008, 2010) hypothesised that, in depression-prone individuals (as well as anxiety-prone individuals; Watkins, 2010), mood state is less effective at shifting the level of identification used to represent difficult events or actions and negative circumstances.
In the concluding discussion a set of design dimensions are presenting, representing difficult trade-offs that needs to be handled during the design process.
