Moreover, in strong contrast to the liver [11] was the finding that catabolic situations per se do not represent a trigger able to induce oxidative stress.
A recent study with a case crossover design suggests that transient exposure to coffee might represent a trigger of a first nonfatal myocardial infarction [6].
To narrow down possible candidate proteins, those most likely to represent a trigger for BNP pathogenesis are presented in this study, giving a fundament for further analysis in future research.
Of special interest here is the heat-shock, as the data indicate that this might represent a trigger for chromatin remodelling, not only to activate individual HSP genes but for remodelling many more chromosomal loci.
Since we found normal proliferation and survival rates of vSMCs in ApoE−/−FNMxCre mice, we conclude that the vascular FN deposits represent a trigger for the recruitment of vSMCs.
As it was already shown that the reduction of oxygen supply is an important external stimulus contributing to limb and cartilage morphogenesis and due to the confirmatory results from the two independent systems, hypoxia could represent a trigger of AP-2 ε expression throughout chondrocyte differentiation [ 12, 33].
They represent a triggering event that, in many cases, leads to large-scale turbulent mixing.
Clinical observations also report that FMS patients with concurrent headache, particularly migraine, often present an exacerbation of their typical FMS symptomatology in concomitance with or immediately subsequent to a headache attack, suggesting that headache may represent a triggering factor for fibromyalgia pain.
Therefore, chronic inflammation could represent a triggering factor in the origin of MetS, with cytokine hypersecretion, leading to insulin resistance and diabetes in genetically or metabolically predisposed individuals.
