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The observation that even healthy subjects experience deterioration in cardiac function and energy metabolism in the context of sustained hypoxia represents a rationale for this pathological sequence.
These results suggest that the PKA pathway could be activated in human cancer cells with intrinsic resistance to selective MEK inhibitors and represents a rationale for the investigation of combining MEK and PKA inhibitors in cancer treatment.
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Yet it was difficult to gauge the extent to which that and other variables represented a rationale for white Democrats who were disinclined to support a black candidate.
Such radiation-induced activation of EGFR-dependent processes may represent a rationale for combined treatment with radiation and EGFR inhibitors.
This finding is in particular intriguing as it may represent a rationale for a targeted therapy with specific tyrosine kinase inhibitors such as c-KIT blockers in mucosal melanomas.
The effects of creatine supplementation on muscle performance and protein metabolism and, possibly, muscle integrity may represent a rationale for its potential use to prevent or treat muscle disorders.
A failure of the patient to respond adequately, and for the drug to show minimal impact on psychiatric symptoms, represents a major rationale for antipsychotic drug switching.
This represents a good rationale for using the HADS as a unitary measure because it suggests that, in this population, the HADS could not discriminate between anxiety and depression.
Nephrotoxicity associated with CMS and aminoglycosides after intravenous infusion represents an additional rationale for their nebulized delivery.
Thus, these results represent a strong rationale for follow-up studies addressing combination therapies of Danusertib with IM and potentially, 2nd generation tyrosine kinase inhibitors such as Nilotinib, Dasatinib and Bosutinib in order to improve therapeutic effects in BCR-ABL-positive leukemias.
These rankings represent a systematic rationale for informing chemical prioritization decisions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com