Sentence examples for represents a rationale from inspiring English sources

The observation that even healthy subjects experience deterioration in cardiac function and energy metabolism in the context of sustained hypoxia represents a rationale for this pathological sequence.

These results suggest that the PKA pathway could be activated in human cancer cells with intrinsic resistance to selective MEK inhibitors and represents a rationale for the investigation of combining MEK and PKA inhibitors in cancer treatment.

In conclusion, we showed that SHH pathway could be involved in the self-renewal, proliferation, drug resistance and tumorigenic of tumorsphere cells and suggest that strategies aimed at inhibiting SHH pathways represent a rationale therapeutic approach to target gastric CSCs.

Such radiation-induced activation of EGFR-dependent processes may represent a rationale for combined treatment with radiation and EGFR inhibitors.

This finding is in particular intriguing as it may represent a rationale for a targeted therapy with specific tyrosine kinase inhibitors such as c-KIT blockers in mucosal melanomas.

The effects of creatine supplementation on muscle performance and protein metabolism and, possibly, muscle integrity may represent a rationale for its potential use to prevent or treat muscle disorders.

The coexistence of high- and low-molecular-weight surfactants, for instance, in addition to the role played by CO2, can represent a rationale to interpret the debate over the foam-promoting role of robusta coffee in espresso blending or the peculiar foam adhesion observed in pure robusta espresso.

Specific targeting of cellular survival and stress resistance due to NEFH deficiency represents a new rationale therapeutic strategy in human cancer.

A failure of the patient to respond adequately, and for the drug to show minimal impact on psychiatric symptoms, represents a major rationale for antipsychotic drug switching.

4 The reduction of cerebral IPC with age represents a strong rationale to induce IPC in elderly patients to therefore decrease stroke-related mortality.

This represents a good rationale for using the HADS as a unitary measure because it suggests that, in this population, the HADS could not discriminate between anxiety and depression.