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The high participation rate indicates that the study cohort represents a migraine population without any serious selection bias.
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In other terms, observed FPN connectivity changes may represent a migraine biomarker, probably related to well-known maladaptive stress response in migraine patients.
This in our opinion is also due to the misclassification of FHM as a subtype of MA [2], whereas FHM represents a syndromic migraine (see below).
The decision not to include patients who already undertook regular exercise could be criticized, as individuals who are unaccustomed to exercise do not necessarily represent a typical migraine population, 6) although migraine sufferers in general have been found to exercise less with the increasing severity of the disease (12).
Although it is not known if the reduction of endothelial progenitor cells represents a primary alteration in migraine or the consequence of migraine attacks, it might be possible that their alteration mediates the increased vascular risk.
Chronic Migraine (CM), with or without medication overuse headache (MOH), represents a therapeutic challenge in migraine management.
Migraine represents a common pain disorder, with a prevalence in the general population of 11%% [1].
Migraine represents a burdensome group of elderly patients in our headache clinic.
Impaired habituation probably represents a neurophysiological marker of migraine [8, 11, 21].
Migraine represents a public health problem with an enormous burden to both individual patients and society [2].
In both conditions, migraine represents a defined risk factor although the magnitude of the risk varies across the different studies.
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