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DG allocation is a hot area of research and represents a difficult problem in electrical power engineering.
At the present stage of GSM TIP model development the use of a realistic geomagnetic field represents a difficult problem which requires the development of an absolutely new model.
The treatment of complex 3- and 4-part fractures of the proximal humerus with high risk of avascular necrosis represents a difficult problem for the surgeon.
Phylogenetic analysis represents a difficult problem computationally because the number of trees increases super-exponentially with the number of species in the analysis.
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However, designing an optimal spatial layout of treatment units represents a difficult optimization problem.
However, the identification of an informative subset of motifs represents a difficult combinatorial problem.
Osteomyelitis associated with infected overlying wounds represents a difficult diagnostic and therapeutic problem; bone biopsies can be done during debridement of the overlying wounds, but it is unclear how often the results of these bone cultures actually affect subsequent antibiotic decisions.
This work addresses the problem of efficient control of gene expression in the context of viral vectors, which still represents a difficult challenge.
For India, in some ways, Australia represents a difficult case.
For patients, it can be a difficult problem to navigate.
It appears to be a difficult problem, but academics are used to dealing with difficult problems.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com