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To the best of our knowledge, 1is representing the first example of FONs as chemosensor for nanomolar detection of Cs+ in aqueous media.
Representing the first example of an antibody drug conjugate (ADC), calicheamicin γ1I was introduced as a clinical agent marketed by American Home Products under the name of Mylotarg for the treatment of leukemia.
The fluorinated compound exhibited potent vacuolar-type ATPase (V-ATPase) inhibitory activity, comparable to that of the natural product, representing the first example of highly bioactive analogues with a modified macrolactone core from the plecomacrolide family compounds.
The use of (oxazolinylferrocenyl phosphine L29 enabled formation of 272 in good yield and moderate ee, representing the first example of an arylboron reagent being used in asymmetric allylic arylation (Scheme 38 ).
Some of the worm ALT strains have now been grown for >180 generations in the laboratory, representing the first example of a multicellular organism with canonical telomeres that can propagate despite an abrogated telomerase pathway.
The crystal structure of βSS12 in complex with 14-3-3 14-3-3 14-3-3figurevealsof the baconfigurations very similar tofthe initial turn motif, therebackbonesenthat the fisst example of an artificially stabilized turn motif.
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The latter compound represents the first example of all-carbon linked arabinofuranotriose analogue.
This work represents the first example of MOFs applied to the catalytic hydrolysis of COS.
P19 represents the first example of a GPCR-specific RNA aptamer.
The important family of alcohols represents the first example of the method, which is compared with other existing methods.
To our knowledge, mapmodulin represents the first example of a protein that can bind and potentially regulate multiple MAP proteins.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com