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Similar to schizophrenia, associations between the proxies representing alterations in the different DA tracts may be hypothesized for bipolar disorder as well.
In addition, urine serves as a protein/peptide reservoir representing alterations in renal diseases [ 3, 4], non-renal localized conditions [ 5, 6] and systemic illnesses [ 7, 8].
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Recent approaches have enabled genomewide studies of 5mC distribution and demonstrated that the pattern changes during early mouse embryogenesis [ 4] and adult mouse stem cell differentiation [ 5], representing alteration of local epigenetic states in differentiating cells.
Key representative markers for the present study are chosen in order to correctly represent alterations in: inflammation (hs-CRP), risk of atherosclerotic plaque rupture and matrix turnover (MMP-9), and platelet reactivity (aggregability tests).
Diffusion abnormalities represent alterations in the random movement of water molecules in tissues, revealing their microarchitecture, and occur in many neurological conditions.
Total RNA-seq of EZ-SEZ/SVZ tissue can only represent alterations in the overall transcription profile, while ignoring changes in individual subsets of cells.
Changes in these mechanics probably represent alterations in the arterial wall.
These stage-specific miRNA profiles may represent alterations in exosomally secreted miRNAs during cancer progression.
Statistically significant differences between the prospective and retrospective cohorts likely represent alterations in the standard of care over time.
Statistically significant differences between the handwritten and PDA groups likely represent alterations in the standard of ED care over time.
Changes in the intrinsic activity of resting-state networks are presumed to represent alterations in functional brain connectivity and may mark neurodegeneration in an early, presymptomatic stage.
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