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The TMA "incidental PCa" is assumed to contain mostly indolent tumors, whereas the TMA "lymph nodes" were made of metastases, thus representing aggressive cancers.
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In general, these xenografts represented aggressive TNBC.
The data sets we selected represent aggressive and non-aggressive endometrial cancer cases, separately.
These similarities indicate that the groupings used in this study represent aggressive and submissive animals.
The included haematological malignancies were chosen to represent aggressive malignancies that frequently require urgent inpatient treatment.
These cells are commonly used in experimental models to represent aggressive, basal-like, triple-negative human breast cancer cells.
Except of follicular lymphoma as an indolent type of NHL, all other histologic subclasses represent aggressive type.
Finally, bladder cancers harboring a beta-catenin mutation may represent aggressive biological behavior with enhanced proliferating activity [ 44].
Malignant mixed Mullerian tumours (MMMTs) of the uterus and adnexa represent aggressive gynaecologic malignancies with a high rate of loco-regional and distant failure.
Carcinosarcomas of the female genital system, also termed MMMTs, represent aggressive malignancies often diagnosed at advanced stages (III or IV) in the majority of cases.
Recent studies found the tumors with high expression of miR-34a represented aggressive breast cancers but the tumors with lower expression suffered from significantly increased tumor recurrence [ 45].
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