Exact(1)
The heatmaps of URDEGs of these clusters represented the same expression pattern as analysed by our method (Fig. 7).
Similar(59)
Where multiple probes represented the same gene, the expression for the gene was summarized with the average value.
If multiple probe sets represented the same gene and they showed same direction of expression, the probe set with the highest variance was used.
On that basis, disease marker and eQTL marker SNPs are considered to represent the same underlying expression mechanism if they are identical, or within 0.05 centiMorgans of each other.
Importantly, the majority of neutrophils in this tissue is of the Gr-1high phenotype and represents mature neutrophils displaying the same expression profile of classical activation markers upon stimulation as cells isolated by positive selection.
In case of multiple probes representing the same gene average expression values were used.
In detail, we compared our results (averaged across arrays representing the same tissue comparison) with expression data obtained by Ge et al. [ 58], who hybridized RNA from each of 36 normal human tissues singly to Affymetrix oligonucleotide microarrays to determine expression levels of around 20,000 human genes (see Methods).
Transcripts with the same expression patterns but so far unknown function could represent further candidates for regulators of P homeostasis.
Furthermore, we collapsed the matched clones representing the same gene by their mean expression value (Figure 1A).
It suggests, in most cases, that probes representing the same gene indeed have similar expression profiles.
These findings indicated that the clustering analysis is robust, grouping probe sets representing the same genes based on similar expression patterns.
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