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GO 0045786 (Negative regulation of cell cycle) is the most prominent disproportionately represented term.
In the cellular compartments category, 'cell part' (29%) was the most represented term, followed by 'membrane-bounded organelle' (20%) and 'organelle part' (16%) (data not shown).
Within these biological processes, the most significantly over represented term was oxidation-reduction process (GO 0055114, 92 genes within this term).
The most represented term in the 351-gene set is response to stress, which included 78 genes from the set (24.5%) and was significantly (p = 9.4 × 10−5) enriched with respect to the total of 26,184 genes (16.2%).
In the molecular function category, "binding" (41.8%) was the most dominant term, followed by "catalytic activity" (36.6%); in the cellular compartments category, "cell part" (42.91%) was the most represented term, followed by "membrane-bounded organelle" (29.34%) and "organelle part" (10.04%).
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Functional Group 15 represented terms linked with amino acid metabolism, suggesting an emphasis on protein synthesis.
For the biological process category, response to salt stress and cadmium ion were the most highly represented terms (Fig. 1).
In the BP category, the two most represented terms are "transcription" (1.82 % +/− 0.09 %) and "regulation of transcription" (1.81 % +/− 0.17 %).
In the molecular function ontology class, the most represented terms describe catalytic (33.3%) and hydrolase activity (20.0%).
The annotated GO terms in each cluster were fixed at level 2. The most represented terms in each cluster were mainly associated with metabolic and cellular processes.
𝒴 represents each HPO subontology in a vector space where component i represents term i.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com