These are represented in modules 2 (constantly downregulated gene sets, e.g. cholesterol biosynthesis, glutathione metabolism and metabolism of xenobiotics by cytochrome P450) and module 4 (constantly upregulated gene sets, such as lipoprotein metabolism).
The reciprocal transcriptional profiles of the pathways represented in modules 1 and 5 emerge as the principal signature of the transition from early to late hepatic transcription response to excess dietary fat.
The major water responsive transcripts represented in the module included dehydrin, osmotin, LEA protein, expansin, arabinogalactans, heat shock proteins, major facilitator proteins, ARM repeat proteins, raffinose synthase, tonoplast intrinsic protein and transcription factors like DREB2A, ARF9, AGL24, UNE12, WLIM1 and MYB66, MYB70, MYB 55, MYB 16 and MYB 103.
Among the genes represented in the module, three genes have a described function associated with ROS generation.
The ophthalmology residency intake is represented in the module as a policy variable determined yearly by policy makers.
As represented in the module diagram, the stock of medical students increases via admissions and decreases via dropout and graduation.
For that, we calculated the probability of the DEG being significantly represented in each module compared to 10,000 simulated sets of genes generated randomly from the microarray background.
While Red and Pink modules clearly separate amygdala and hippocampus in these two strains, the functions represented in these modules may extend to other (brain) regions as well.
