Despite this controversy, the Sargasso Sea dataset represented a ground-breaking metagenomic survey because of its sheer size and the novel functional diversity it revealed, especially in terms of the broader photosynthetic capability of oceanic microbes [3].
The obtained MOS, in particular, represents a ground truth for the development of objective quality metrics.
Interestingly, the FtsY·Ffh-NG complex structures also suggest that (i) the structures observed represent a ground state of the GTP hydrolysis reaction, and (ii) that additional conformational changes in the active site are necessary to progress to the transition state.
The HMC, by contrast, appears to lack specific determinants and might represent a ground state of MNs.
From an epigenetic point of view, germ cells represent a ground state from which differentiation into particular cell types is accompanied by specific DNA and chromatin modifications [ 66].
We have proposed that ES cells represent a ground state for mammalian cells, meaning a basal self-replicating unit that is developmentally and epigenetically un-programmed and has minimal requirements for extrinsic stimuli to support survival and proliferation (Silva & Smith, 2008).
This study represents a ground-breaking oral health initiative that has the potential to deliver a cost-effective oral health intervention during pregnancy delivered by a unique partnership of health professionals.
Adoption of the SOPs, and of the surgical and clinical data collection instruments described in our previous articles (20, 21), represents a ground-breaking opportunity for endometriosis research centers to decrease variability in and increase validity of their results, and to allow new comparisons and collaborations among centers (1, 19).
He also said such an education gap represented a breeding ground for extremism.
"For many white Americans," the historian Eric Foner has written, "colonization represented a middle ground between the radicalism of the abolitionists and the prospect of the United States' existing permanently half slave and half free".
Mr. McCracken represented a middle ground between Johnson's advisers, who had advocated "fine-tuning" tax policies to regulate the economy, and the conservative, laissez-faire approach of the Chicago school, led by Milton Friedman.
