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The present paper describes the results of a design exercise in which robust controllers were designed for a representative vessel.
In this study, a more realistic definition of the EEDI is proposed, which is based on a number of representative vessel operating points.
A representative vessel (Fig. 6B, black arrowheads) seemed to completely disappear at the end of both rapamycin treatment cycles (day 3 and day 14) but became visible again during the rapamycin 'off period' (day 6 and day 9) in the same location.
Carroll et al. [ 33] used the minimum rCBV in a representative vessel area, Grandin et al. used the mean rCBV plus 1 standard deviation [ 9], and Ernst et al. applied a threshold of 2.5 times the median of rCBF values for all voxels [ 32].
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During the examinations of suspected patients in some cases, no representative vessels were detected.
Only a single subject, in whose biopsy no representative vessels of correct size were identified, was excluded from the study.
In only one NOTCH3 mutation positive patient, we did not find representative vessels in the only available biopsy, and thus, the presence of GOM could not be determined.
Additionally measured endothelial cells representative for vessel integration and myofibroblasts were all negative during the initial 120 min after implantation.
Podoplanin, which is a representative lymphatic vessel marker (D2-40), have gained attention as a CAFs' marker, and the podoplanin-expressing CAFs has been reported to be associated with malignant potential in several types of cancer (Pula et al, 2011; Neri et al, 2012; Shindo et al, 2013).
The blood flow changes can be visualized by comparing some representative blood vessels, such as the ones pointed by arrows V1, V2 and V3 in Figs. 2 (B) and (D).
"We'll work as hard as we can, as long as we can, to save this beautiful vessel," Representative Steve Chabot, a Republican from Cincinnati, told a crowd of 200 to 300 supporters gathered near the boat before it departed.
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