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The presence of the chocolate-spot-associated virus in representative symptomatic leaves of sap-inoculated and grafted tomato plants was confirmed by RT PCR analysis (data not shown).
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This patient population was therefore representative of symptomatic primary breast cancers in a Western country.
Nonetheless, the sample might not be representative of symptomatic breast cancer patients in general and we cannot know how many people were made aware of the trial through these recruitment procedures.
The area under the ROC curve for the alternative reference groups is very low, possibly because the viral loads in many of the IID cases in the reference positive group were not representative of symptomatic norovirus infection; this is reflected in the low sensitivity for the cut-off at Ct value 31 when using these groups in the ROC analysis.
Consequently, control women undergoing laparoscopy for sterilization are unlikely to be representative of the symptomatic population from which cases were drawn; indeed community or symptomatic hospital-based controls would be more representative (34).
Additional serologic studies in representative samples of symptomatic and asymptomatic travelers are needed to investigate the risk in defined areas.
Even though only a small proportion of those surveyed attended research clinics the CASK sample has been shown to be representative of the symptomatic general population and similar analyses in CASHA resulted in the same conclusions.
These two restrictions were used to ensure that norovirus was the most likely cause of their illness and to ensure that their faecal viral load is representative of acute symptomatic norovirus infection [ 12, 22, 23].
The regional symptomatic representatives of ABS are encouraged to review participation in their own areas and to identify ways in which this could be improved.
The demographic considerations of the patients participating were representative of women with symptomatic breast cancer at presentation [ 1].
The regional symptomatic surgical representatives contacted the lead breast surgeon in each hospital, seeking his (or her) help in collecting their colleagues' written consent to release data.
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