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Appendix A1 also contains dialogue from a representative screening interview in one patient.
Fig. 1 A representative screening plate used for selection of UV mutants.
With the rapid increase of the number of commercially available small molecules, analysis of the structural features and scaffold diversity for representative screening libraries is quite demanding.
We assessed whether the inclusion and exclusion criteria were described clearly and would result in a representative screening cohort.
Representative screening 'hits' that included compounds with varying degrees of isoform selectivity were titrated, and the Ki values were determined in the absence of lipids (Table 3).
To have a representative screening, we used eleven primer combinations that together amplify a wide range of precursors (Additional file 1).
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(a) FLT values from one representative screen including DMSO control wells with a Hit threshold (>3 S.D. of mean) indicated by dotted blue lines.
A representative screen shot is shown.
Data from one representative screen of the RealTime-Glo MT Cell Viability Assay are summarized in Supplementary Table S1 (Supplementary Data are available online at www.liebertpub.com/adt).
Figure 3E shows a representative screen shot of one of the regions in which H3K4me1 occupancy was found to be reduced in Rlf homozygous mutants.
YHD representatives screened all purchase offers and handled the contract negotiations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com