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In the context of pediatric CKD, India has emerged as a 'hotspot' that is probably representative of the burden of CKD that exists in South Asia.
Such results would be less representative of the burden of risk factors in 2004 (partly because of loss to follow-up) and therefore less applicable to public health action.
Furthermore, there is evidence to suggest that ratings of 'worst' pain are more representative of the burden experienced by patients in relation to pain and may be more reliable to report; given that when a patient with persistent pain thinks back to their pain over a period of time, they tend to focus their response on their 'worst pain' even when asked about their 'average pain [ 38, 39].
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In this first nationally representative study of the burden of the metabolic syndrome in the Middle East, we found alarming prevalence rates of the syndrome and its components as defined by different sets of criteria.
Whether the density of LN in the SMP is representative of the pathology burden in the MP is still an open question that could be addressed by a comparative and comprehensive analysis of the myenteric and SMP in surgical or postmortem specimens.
Second, the biopsy may not be representative of the total burden of mutated cells, especially in patients with metastases.
The primary limitation of the current analysis is that the studies were conducted during three influenza seasons, which may not be representative of the average burden of influenza in Europe and Israel.
Although these patients comprise a subset of oral cancer patients diagnosed during this period, there were no significant differences in clinical and demographic characteristics between these patients and our population-based prospective clinical cohort diagnosed between 2009 and 2012, indicating that these patients are representative of the disease burden in Alberta, Canada (data not shown).
Measurements of lesion volume provide a more representative of the total lesion burden in an artery[3], and are therefore not subject to the bias and error introduced by selection of particular portions of the vessel for analysis.
Importantly, a single measurement of inflammatory cytokines is not representative of the total inflammatory burden of RA patients.
Another limitation is that calcification of coronary plaque may not be equally representative of the same atherosclerotic burden in RA patients as controls, since noncalcified soft plaque is not detected by Agatston scoring [ 37].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com