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Representative derivatives of the newly synthesized compounds were tested.
Meanwhile, the cytotoxicity of 20 representative derivatives was tested in the human tumor cells line (HepG2) and the hepatic L02 cells line, the result indicated that the synthesized compounds showed significant inhibitory activity and limited selectivity.
To evaluate the applicability of CMA-BODIPYs for live cell imaging, we interrogated representative derivatives for their ability to penetrate mammalian cell membranes and their propensity for nonspecific background staining.
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One representative derivative, 4-amino-3- 4- benzenesulfonylamino -phenyl -2- 3-pyridyl -furo[2,3-d]pyrimidine (12) exhibited potent GSK-3β inhibitory activity in low nanomolar level of IC50.
Representative azaindole derivatives showed activity in a cellular proliferation and apoptosis assays.
A chemo-enzymatic two-step process was also designed successfully, and several representative spirooxindole derivatives could be obtained in nearly quantitative yields.
In the present study, quantum chemical calculations were performed for several representative fullerene derivatives in order to determine their frontier orbital energy levels and electronic structures, thereby helping to enhance their performance in PSC devices.
Characterization of representative KL001 derivatives.
We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection.
To further probe the persistence of the chemical integrity of the dyes and identify fluorescent degradation products that would not result in reduction of overall fluorescence we also monitored the stability of representative BODIPY derivatives over 24 h in PBS by LC-MS.
KTA-439 (29), a representative indane derivative, showed the same high human TRβ selectivity in a binding assay as 3 and higher liver selectivity than 3 in a cholesterol-fed rat model.
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