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In some cases, they may also be used to select representative at-risk subpopulations to increase the sensitivity of the study.
The current study recruited participants accessing HIV prevention or testing services, and may not be representative of at-risk populations who do not access these services.
The retrospective surveys that investigators conduct to remedy the problem may be not be representative of the at-risk populations.
That said, the obesity had developed naturally and been longstanding (e.g. >12 months) in most cases, which is arguably more representative of the at-risk population of interest.
"We shouldn't hang around and wait for national legislation to be imposed one state at a time, because it could take years before each country puts in place the right sort of disincentives," argued Chris Carroll, a representative of Seas at Risk, an environmental group based in Brussels that is seeking action at the E.U. level.
Also the population-based controls are representative of those at risk of disease.
We enrolled neonatal deaths from two urban hospitals which may not be the representative of population at risk of the entire country.
Note that our study cohort was selected from a population of patients and affiliates of our Division of Clinical Nutrition and Nutrigenomic: although it was not taken at random from the Italian population, this sample can be regarded as representative of women at risk and requiring medical examination.
Participant eligibility requirements included age ≧15 years (to encompass FSWs representative of those at risk for STIs); ability to give consent; and having provided commercial sex in sex-work venues or rented apartments for money or goods within the previous three months.
FSWs were recruited by outreach workers and eligibility requirements included age > 16 years (to encompass FSWs representative of those at risk for STIs); ability to give consent; and having provided commercial sex in sex-work venues or rented apartments for money or goods within the previous three months.
Another strength is that this study is the first to make a nationally representative assessment of the at-risk population for development of diabetes and then use that assessment to model the future prevalence of diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com